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ASSIGN: Whenever attributes and variables are used in a model they need to be assigned values during model execution. Human induced pluripotent stem cells (hiPSCs) are already proved useful as platforms for studying disease mechanisms, pharmacological responses, and toxicology in patient- and healthy proband-cardiomyocytes (hiPSC-CMs). 1, 2 These hiPSC-CMs are usually not derived as a homogenous population of cells but consist of different subtypes with ventricular-, atrial-, and nodal-like properties. 3 – 5 While this can be advantageous because it allows the study of physiology and disease mechanisms in all three major CM subtypes, it also poses a challenge, since phenotypes might be obscured by varying contributions of the different CM subtypes.

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