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Download Apoptosis, Senescence and Cancer (Cancer Drug Discovery and by David A. Gewirtz, Shawn E. Holt, Steven Grant PDF

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By David A. Gewirtz, Shawn E. Holt, Steven Grant

This publication offers perception into demonstrated practices and study into apoptosis and senescence. the quantity completely examines novel and rising ideas and examine within the fields of mobilephone dying pathways, senescence progress arrest, medicines and resistance, DNA harm reaction, and different subject matters that also carry mysteries for researchers. In overall, this quantity offers easy scientists and clinicians with a deeper and extra whole figuring out of the mobile responses of malignancies that could ascertain the effectiveness of therapy, either within the preliminary phases of the disorder in addition to in illness recurrence.

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139. Dent P, Grant S. Pharmacologic interruption of the mitogen-activated extracellular-regulated kinase/mitogen-activated protein kinase signal transduction pathway: potential role of promoting cytotoxic drug action. Clin Cancer Res 2001; 7:775–83. 140. Ley R, Balmanno K, Hadfield K, Weston C, Cook SJ. Activation of the ERK1/2 signaling pathway promotes phosphorylation and proteasome-dependent degradation of the BH3-only protein, Bim. J Biol Chem 2003; 278:18811–6. 141. Luciano F, Jacquel A, Colosetti P, et al.

98. Stoka V, Turk B, Schendel SL, et al. Lysosomal protease pathways to apoptosis. Cleavage of bid, not pro-caspases, is the most likely route. J Biol Chem 2001; 276:3149–57. 99. Gajewski TF, Thompson CG. Apoptosis meets signal transduction: elimination of a BAD influence. Cell 1996; 87(4):589–92. 100. Puthalakath H, Huang DCS, O’Reilly LA, King SM, Strasser A. The proapoptotic activity of the Bcl-2 family member Bim is regulated by interaction with the dynein motor complex. Mol Cell 1999; 3:287–96.

Constitutive activation of Stat3 signaling confers resistance to apoptosis in human U266 myeloma cells. Immunity 1999; 10:105–15. 126. Epling-Burnette PK, Liu JH, Catlett-Falcone R, et al. Inhibition of STAT3 signaling leads to apoptosis of leukemic large granular lymphocytes and decreased Mcl-1 expression. J Clin Invest 2001; 107(3):351–62. 127. Wang JM, Chao JR, Chen WS, Kuo ML, Yen JJ, Yang-Yen H-F. The antiapoptotic gene mcl-1 is up-regulated by the phosphatidylinositol 3-kinase/Akt signaling pathway through a transcription factor complex containing CREB.

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