Download Biology, Computing, and the History of Molecular Sequencing: by M. García-Sancho PDF
By M. García-Sancho
Sequencing is frequently associated with the Human Genome venture and celebrated achievements in regards to the DNA molecule. notwithstanding, the historical past of this custom contains not just educational biology, but in addition the area of computer-assisted details administration. The publication uncovers this heritage, qualifying the hype and expectancies round genomics.
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Additional info for Biology, Computing, and the History of Molecular Sequencing: From Proteins to DNA, 1945–2000
D. Bernal, a charismatic and unorthodox character, who became the first leader of the Cavendish crystallographic group (Brown, 2007). Dorothy Hodgkin was educated there before moving to Oxford and focusing on the three-dimensional structure of insulin (see Chapter 1). In 1937, Bernal migrated to Birkbeck College London, having been disappointed not to obtain a senior position at Cambridge, partly due to his Marxist politics (Olby, 1992 , ch. 16). 39 40 Emergence The end of World War II and the search for peacetime applications for both the technologies and researchers involved in wartime physics projects gave new impetus to the Cavendish group.
A more formalised and productive association was that of Sanger with Vernon Ingram, another visitor from the US investigating sickle-cell anaemia. This disease, and the structural alteration of haemoglobin which caused it, was a major line of research at the Cavendish and the object of X-ray analyses by crystallographer Max Perutz. 3 The potential of co-operation with Sanger led Crick and Brenner to intensify their efforts to attract him to the Cavendish Laboratory. They wanted Sanger to carry on applying his protein techniques to the coding problem and begin developing methods for the sequence determination of RNA and DNA.
158) and that, to determine its structure, it was necessary to analyse it physically and chemically, rather than mathematically: Clearly the analyst ( ... ) can contribute but little on his own, and there is need for more co-operation with the physical chemist and crystallographers, who are able to investigate the properties and structure of ( ... ) the intact protein molecule itself. ( ... ) Meanwhile, I think that those interested in proteins would be wise to regard the Bergmann– Niemann hypothesis as still tentative and in any case as applicable only to the component peptide chains of the molecule, for much of the evidence hitherto brought forward to support it has been based on inadequate experimental data and has demonstrated nothing more than the hypnotic power of numerology.