Radiology Nuclear Medicine

Download Cancer nanotechnology: principles and applications in by Sang Hyun Cho, Sunil Krishnan PDF

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By Sang Hyun Cho, Sunil Krishnan

Rapid advances in nanotechnology have enabled the fabrication of nanoparticles from a variety of fabrics with assorted shapes, sizes, and homes, and efforts are ongoing to take advantage of those fabrics for useful medical functions. Nanotechnology is especially appropriate within the box of oncology, because the leaky and chaotic vasculature of tumors―a hallmark of unrestrained growth―results within the passive accumulation of nanoparticles inside tumors.

Cancer Nanotechnology: ideas and functions in Radiation Oncology

is a compilation of analysis within the area of nanoparticles and radiation oncology, which lies on the intersection of disciplines as different as scientific radiation oncology, radiation physics and biology, nanotechnology, fabrics technology, and biomedical engineering. The booklet offers a entire, cross-disciplinary survey of simple rules, study strategies, and results with the objectives of eventual scientific translation.

Coverage includes

  • A common advent to fabrication, preferential tumor concentrating on, and imaging of nanoparticles
  • The particular functions of nanomaterials within the nation-states of radiation treatment, hyperthermia, thermal treatment, and general tissue defense from radiation exposure
  • Outlooks for destiny examine and scientific translation together with regulatory concerns for final use of nanomaterials in humans
  • Reflecting profound advances within the program of nanotechnology to radiation oncology, this accomplished quantity demonstrates how the original physicochemical houses of nanoparticles result in novel suggestions for melanoma therapy and detection. in addition to a number of computational and experimental concepts, each one bankruptcy highlights the main promising ways to using nanoparticles for radiation reaction modulation.

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    Additional info for Cancer nanotechnology: principles and applications in radiation oncology

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    Indeed, the response of normal tissues and tumors to radiation reflects the four “R’s” of radiation therapy and biology: repair, redistribution, reoxygenation, and repopulation (Withers 1975; Kallman 1972). For normal tissues, fractionation of a radiation dose is beneficial because such tissues divide slowly and may be able to repair the radiationinduced damage to the DNA. “Redistribution” refers to the relative proportions of cells at different points in the cell cycle. Cells in M (mitotic) phase are the most sensitive to radiation, whereas cells in S phase are the most resistant.

    R. Stockigt. 1992. Characterization of cytoplasmic T3 binding sites by adsorption to hydroxyapatite: Effects of drug inhibitors of T3 and relationship to glutathione-S-transferases. Thyroid 2(1):39–44. , and J. Lukas. 2007. DNA damage checkpoints: From initiation to recovery or adaptation. Current Opinion in Cell Biology 19(2):238–245. , T. R. O’Connor, and J. Laval. 1987. Formamido­ pyrimidine-DNA glycosylase of Escherichia coli: Cloning and sequencing of the fpg structural gene and overproduction of the protein.

    Bethesda, MD: International Commission on Radiation Units and Measurements. International Commission on Radiation Units and Measurements. 1999. Prescribing, Recording, and Reporting Photon Beam Therapy. Bethesda, MD: International Commission on Radiation Units and Measurements. Johns, H. , and J. R. Cunningham. 1983. The Physics of Radiology. 4th ed. Springfield, IL: Charles C. Thomas. Karzmark, C. , and R. J. Morton. 1998. A Primer on Theory and Operation of Linear Accelerators in Radiation Therapy.

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