Download Decision Tools for Radiation Oncology: Prognosis, Treatment by Carsten Nieder, Laurie E. Gaspar PDF
By Carsten Nieder, Laurie E. Gaspar
A examine the hot oncology literature or a seek of the typical databases unearths a gradually expanding variety of nomograms and different prognostic types. those versions may perhaps are expecting the chance of relapse, lymphatic unfold of a given malignancy, toxicity, survival, and so on. Pathology info, gene signatures, and medical information may well all be used to compute the versions. This development displays more and more individualized therapy strategies, the necessity for methods that in achieving a positive stability among effectiveness and side-effects, and the aim of optimum source usage reflecting prognostic wisdom. as a way to steer clear of misuse, it is very important comprehend the bounds and caveats of prognostic and predictive versions. This publication presents a finished evaluate of such determination instruments for radiation oncology, stratified by means of ailment website, with a purpose to allow readers to make proficient offerings in day-by-day medical perform and to seriously persist with the longer term improvement of recent instruments within the field.
Read or Download Decision Tools for Radiation Oncology: Prognosis, Treatment Response and Toxicity PDF
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Extra info for Decision Tools for Radiation Oncology: Prognosis, Treatment Response and Toxicity
2010). In this analysis, frozen tumor specimens from 148 women, aged 55-70 years old with tumor size\5 cm and negative lymph nodes, were analyzed and assigned either good or poor prognosis based on their 70-gene signature. 036). 07). Currently, there are several ongoing clinical trials designed to further characterize the utility of Mammaprint. MINDACT (Microarray In Node-negative and 1-3 positive lymph node Disease may Avoid ChemoTherapy; EORTC 10041), is a Phase III prospective randomized study comparing Mammaprint with clinical-pathological assessment (Adjuvant!
Women meeting eligibility criteria will be randomized to receive endocrine therapy with or without the addition of chemotherapy. The primary endpoint is disease-free survival and enrollment is ongoing. Oncotype DX assessment is incorporated in the ASCO recommendations for use of tumor markers in breast cancer and in NCCN guidelines to predict the risk of recurrence for women with ER-positive, HER2-negative, node-negative breast cancer treated with tamoxifen. The NCCN panel considers Oncotype DX an option, to be taken into consideration only in the context of other elements of patient risk stratification.
Fig. 15 First step of nomogram drawing: creation of the covariates scales using a scatter plot with lines that join the values of the same covariate. For the dummy covariates (Factor 1 and Factor 2) only the significant values have to be used, the not significant values have value ‘0’. For the continuous covariate (age) a scale containing predefined intervals has to be created by multiplying each step with the covariate coefficient. The three lines lies on three different levels (given by the y values of the scatter plot) and the x axis shows the value of the score that have to be summed to achieve the exponent of the survival equation variable and S(Tp) as marker in the ROC analysis.