Download Molecular and Applied Aspects of Oxidative Drug Metabolizing by John B. Schenkman (auth.), Emel Arinç, John B. Schenkman, PDF

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By John B. Schenkman (auth.), Emel Arinç, John B. Schenkman, Ernest Hodgson (eds.)

Written by means of major researchers within the fields of biochemistry, molecular biology, genetics, pharmacology, toxicology, biotechnology and melanoma, it is a complete replace on molecular biology and biochemistry of cytochromes P450 and flavin containing monoxygenases. the amount offers professional research of the genetic polymorphism of those enzymes within the health center, in drug discovery and improvement, and dialogue in their position in predisposition for, and prevention of chemical cancer causing agents in people.

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Eberhart D, Parkinson A (1991) Cytochrome-P450 lilA I (P450p) requires cytochrome-bS and phospholipid with unsaturated fatty acids. Arch. Biochem. Biophys. 291:231-240. 33. Shet MS, Faulkner KM, Holmans PL, Fisher CW, Estabrook RW (1995) The effects of cytochrome b5, NADPH-P450 reductase, and lipid on the rate of6~-hydroxylation of testosterone as catalyzed by a human P450 3A4 fusion protein. Arch. Biochem. Biophys. 318:314-321. 34. Tamburini P, Schenkman J (1987) Purification to homogeneity and enzymological characterization of a functional covalent complex composed of cytochromes P-450 isozyme 2 and b5 from rabbit liver.

Poulos T, Kraut J (1980) A hypothetical model of the cytochrome c peroxidase-cytochrome c electron transfer complex. J. BioI. Chem. 255: I 0322-1 0330. 62. Beratan D, Onuchic J, Winkler J, Gray H (1992) Electron-tunneling pathways in protein. Science 258: I 74G-I 741. 63. Davies M, Qin L, Beck J, Suslick K, Koga H, Horiuchi T, Sligar S (1990) Putidaredoxin reduction ofcytochrome P-450cam-dependence of electron transfer on the identity of put ida redox in C-terminal amino acid. J. Amer. Chern. Soc.

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