Download Nuclear Medicine in Pharmaceutical Research (TAYLOR & by M. Frier, A C Perkins PDF
By M. Frier, A C Perkins
This article defines the position and scope of nuclear drugs imaging suggestions (gamma scintigraphy) in pharmaceutical learn, giving info from medical trial info.
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Additional info for Nuclear Medicine in Pharmaceutical Research (TAYLOR & FRANCIS SERIES IN PHARMACEUTICAL SCIENCES)
It is essential that the accuracy of the radionuclide calibrator is known. This should be checked on a regular basis as part of a routine quality assurance programme according to good manufacturing and clinical practice (GMP/GCP). The readings obtained from the calibrator should be checked on a daily basis for all radionuclide settings using a long-lived reference source such as Co-57 or Ra-226 to ensure that the measurements are within the required tolerances (Hevesey, 1923). 5 The Gamma Camera The gamma camera or scintillation camera is the main instrument used for nuclear medicine imaging.
It is important that the distribution of the radiolabel should reflect that of the drug particles and that it is unaffected by the radiolabelling procedure. The most commonly adopted procedure involves extracting Tc-99m-pertechnetate into an organic solvent and evaporating the solution to dryness in an empty aerosol canister. Using a cold transfer process, the contents of a canister of the formulation to be labelled are added to the technetium-containing canister and a metering valve attached (Hardy, 1997).
The readings obtained from the calibrator should be checked on a daily basis for all radionuclide settings using a long-lived reference source such as Co-57 or Ra-226 to ensure that the measurements are within the required tolerances (Hevesey, 1923). 5 The Gamma Camera The gamma camera or scintillation camera is the main instrument used for nuclear medicine imaging. First developed in 1956 by Hal Anger in the United States (IPSM, 1985) this device was originally based on a single circular scintillation crystal coupled to an array of seven photomultiplier (PM) tubes (The Anger Camera).