Radiology Nuclear Medicine

Download Nuclear Receptors as Molecular Targets for Cardiometabolic by B. Staels PDF

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By B. Staels

Nuclear receptors are a relations of transcription elements including forty nine individuals pointed out within the human genome. Nuclear receptors keep an eye on transcription by means of binding to reaction parts within the regulatory areas of goal genes and thereby impact expression of genes serious about differentiation, progress, lipid homeostasis, irritation and immunity. over the last 20 years major advances were made within the knowing of the rules of gene expression by means of nuclear receptors.The wisdom on nuclear receptors has introduced novel remedies for lipid regulate and hormone alternative, and for administration of melanoma and diabetes. for this reason, nuclear receptors are appealing molecular ambitions for layout of treatment for diabetes, weight problems, atherosclerosis, melanoma, irritation and neurodegeneration. the point of interest of this quantity is headquartered at the mechanistic involvement of nuclear receptors in cardiological, metabolic and neurological issues, on attainable clarification of pathways fascinated about pathogenesis, on susceptibility to and prevention of metabolic and neurological issues and at the elements of drug discovering together with chemistry and rational drug layout. This quantity stories contemporary development on nuclear receptors significantly and should intrigue these pursuing curiosity in body structure, pathology and medicine.

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Read or Download Nuclear Receptors as Molecular Targets for Cardiometabolic and Central Nervous System Diseases (Solvay Pharmaceuticals Conferences) PDF

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Additional info for Nuclear Receptors as Molecular Targets for Cardiometabolic and Central Nervous System Diseases (Solvay Pharmaceuticals Conferences)

Sample text

I. W. G. Shackman et al. LXRbeta is required for adipocyte growth, glucose homeostasis, and beta cell function. J. Biol. Chem. 280 (2005) 23024-23031. T. M. Ulven, K. Bamberg et al. Expression of the insulin-responsive glucose transporter GLUT4 in adipocytes is dependent on liver X receptor alpha. J. Biol. Chem. 278 (2003) 48283-48291. J. Berger, C. P. Vicario et al. Decreased expression of the insulin-responsive glucose transporter in diabetes and fasting. Nature 340 (1989) 70-72. T. Garvey, L.

6 (2006) 508-519. A. B. Joseph, C. Marathe et al. Liver X receptor-dependent repression of matrix metalloproteinase-9 expression in macrophages. J. Biol. Chem. 278 (2003) 10443-10449. J. Y. Sheu, M. Schmuth et al. Liver X receptor activators display anti-inflammatory activity in irritant and allergic contact dermatitis models: liver-X-receptor-specific inhibition of inflammation and primary cytokine production. J. Invest. Dermatol. 120 (2003) 246-255. Comment in: J. Invest. Dermatol. 120 (2003) viii-x.

The induction is dependent on de novo synthesis of proteins. Stabilization studies using actinomycin D indicated that insulin stimulation increased the half-life of LXRD transcripts in cultured primary hepatocytes. This effect was confirmed in vivo, rats and mice injected with insulin had an increase of LXRD mRNA levels. Furthermore, deletion of both the LXRD and LXRE genes (double knock-out) in mice markedly suppressed insulinmediated induction of an entire class of enzymes involved in both fatty acid and cholesterol metabolism.

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