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Download The physics of conformal radiotherapy : advances in by S. Webb PDF

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By S. Webb

The Physics of Conformal Radiotherapy: Advances in know-how offers an intensive review of conformal radiotherapy and organic modeling, targeting the underlying physics and technique of 3-dimensional thoughts in radiation remedy. This rigorously written, authoritative account evaluates 3-dimensional therapy making plans, optimization, photon multileaf collimation, proton remedy, transit dosimetry, intensity-modulation thoughts, and organic modeling. it truly is a useful educating consultant and reference for all scientific physicists and radiation oncologists/therapists that use conformal radiotherapy.

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An optimum plan for a given machine may not necessarily be the optimum if one could replace that machine with a different one, perhaps with different energy. However, when physicists speak of optimisation what they generally mean is a method to achieve the best outcome for the patient in terms of predicted tumour control and few complications and often these are reflected in the goal to obtain the best 3D dose distribution. For the purposes of this chapter, this is what we shall mean by optimisation.

Mohan et a1 (1992) chose fields, not necessarily coplanar, so that no parallel-opposed fields occurred. These studies distinguished, for each orientation, two separate components of the field, namely that ‘seeing’ only PTV and that ‘seeing’ PTV and OAR. The radiation beamweights for the former part-fields were traded off against those for the latter creating inhomogeneous dose distributions in the prostate. In Copyright © 1997 IOP Publishing Ltd 38 Developments and controversies in 30 planning this respect the formalism was identical to that of Webb (1991a, 1992b, 1993a).

Iii) Mohan et a1 (1992) pointed out the difficulty of comparing different optimisation schemes in the literature when some are based on biological cost and others are not. Mohan et a1 (1992) included biological response apriori in the cost function whereas Webb (1991a,b, 1992a,b,c, 1993a) constructed a cost function based solely on dose and calculated biological response a posteriori. More recently the 1 C F " H S T work has included biological optimisation (Webb and Oldham 1993). The use of physical and biological objective functions has recently been reviewed by Brahme (1995a).

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